In our moments of need, we accept the prayers of others, so why would we not ask the saints to pray for us?
It can be helpful to choose the Saints that have overcome the trials that you may be currently facing.
"Confess therefore your sins one to another: and pray one for another, that you may be saved. For the continual prayer of a just man availeth much." - James 5:16
"St. Joseph has the power to assist us in all causes, in every necessity, in every undertaking." - St. Thomas Aquinas
“I have been all things unholy. If God can work through me, He can work through anyone.” - St. Francis of Assisi
"We may seek graces but shall never find them without the intercession of Mary." - St Cajetan
"Pray the rosary frequently. It costs so little and it's worth so much!" - St Padre Pio
"If you consider all the saints, you will see that all of them had a devotion to the Blessed Virgin; her intercession is most powerful, she is the Mother of God and the Mother of men." - St. Andre Bessette